Provides both fundamentals and new and emerging applications

Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases.

Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts:

• Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery
• Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules
• Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases
• Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging

Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book.

Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

ASHIM K. MITRA, PhD, is Chairman of Pharmaceutical Sciences at the University of Missouri-Kansas City. Dr. Mitra is also a University of Missouri Curators' Professor and has more than thirty years of experience in the field of ocular drug delivery and disposition. He has been the recipient of research awards from the NIH, AAPS, AACP, ARVO, and other pharmaceutical organizations.

CHI H. LEE, PhD, is Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City, where he teaches undergraduate and graduate pharmacy courses. His research focuses on elucidation of pathological mechanisms and formulation development of microbicidal and cardiovascular devices.

KUN CHENG, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City. His research seeks to develop novel drug delivery systems for siRNA and small molecule drugs. Dr. Cheng is the recipient of the 2011 American Association of Pharmaceutical Scientists (AAPS) New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies.

Part I: Introduction and Basics of Advanced Drug Delivery

1. Physiological Barriers in Advanced Drug Delivery

2. Solubility and Stability Aspects in Advanced Drug Delivery

3. The Role of Transporters and Efflux System in Drug Delivery

4. Biomaterials in Advanced Drug Delivery

Part II: Strategies for advanced drug delivery

5. Strategies of targeted delivery

6. Prodrug and bioconjugation

7. Nanoscale drug delivery systems

8. Stimuli-responsive strategies in advanced drug delivery

9. Implants

10. Aptamer

11. Nanofiber

12. Biomimetic self-assembling nanoparticles

13. Protein/peptide drug delivery

14. Delivery of nucleic acids

15. Delivery of vaccine

Part III: Translational research of advanced drug delivery

16. Regulatory Considerations and Clinical Issues in Advanced Drug Delivery

17. Advanced drug delivery in cancer therapy

18. Advanced drug delivery in cardiovascular diseases

19. Recent Advances in Ocular Drug Delivery

20. Advanced drug delivery against sexual transmitted diseases

21. Advanced drug delivery to the brain

Part IV: Future applications of advanced drug delivery in emerging research areas

22. Cell-based therapeutics

23. Biomedical Applications and Tissue Engineering of Collagen

24. Molecular Imaging of Drug Delivery