Advanced Genetic Analysis: Finding Meaning in a Genome

by R. Scott Hawley (Stowers Institute for Medical Research); Michelle Walker (University of California, Davis)

ISBN13: 9781444313086

ISBN10: 1444313088

Format: eBook

Pub. Date: 2009-04-01

Publisher(s): Wiley-Blackwell

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Summary

Advanced Genetic Analysis brings a state-of-the-art, exciting new approach to genetic analysis. Focusing on the underlying principles of modern genetic analysis, this book provides the 'how' and 'why' of the essential analytical tools needed. The author's vibrant, accessible style provides an easy guide to difficult genetic concepts, from mutation and gene function to gene mapping and chromosome segregation. Throughout, a balanced range of model organisms and timely examples are used to illustrate the theoretical basics. Basic principles - Focuses students attention on the 'how' and 'why' of the essential analytical tools. Vibrant, accessible style provides an easy guide through difficult genetic concepts and techniques. Text boxes highlight key questions and timely examples. Boxes of key information in each chapter, chapter summaries and extensive references - prompt the student to synthesise and reinforce the chapter material. Special reference section addressing a range of model organisms to help provide a particularly relevant context for students' research interests.

Preface
Introduction
Mutation: Types Of Mutations
Dominance And Recessivity
The Genetic Utility Of Dominant And Recessive Mutants
Summary
Gallery Of Model Organisms
Mutant Hunts: Why Look For New Mutants?
Mutagenesis And Mutational Mechanisms
What Phenotype Should You Screen (Or Select) For?
Actually Getting Started
Summary
The Complementation Test: The Essence Of The Complementation Test
Rules For Uing The Complementation Test
How Might The Complementation Test Lie To You?
Second-Site Non-Complementation (SSNC) (Non-Allelic Non-Complementation)
An Extension Of Second-Site Non-Complementation: Dominant Enhancers
Summary
Suppression: A Basic Definition Of Genetic Suppression
Intragenic Suppression (Pseudo-Reversion)
Extragenic Suppression
Transcriptional Suppression
Translational Suppression
Suppression By Post-Translational Modification
Extragenic Suppression As A Result Of Protein-Protein Interaction
Suppression Without Physical Interaction
Suppression Of Dominant Mutations
Designing Your Own Screen For Suppressor Mutations
Summary And A Warning
Determining When And Where Genes Function: Epistasis: Ordering Gene Function In Pathways
Mosaic Analysis: Where Does A Given Gene Act
Summary
Genetic Fine-Structure Analysis: Intragenic Mapping (Then)
Intragenic Mapping (Now)
Intragenic Complementation Meets Intragenic Recombination: The Basis Of Fine-Structure Analysis
An Example Of Fine-Structure Analysis For A Eukaryotic Gene Encoding A Multifunctional Protein
Fine-Structure Analysis Of Genes With Complex Regulatory Elements In Eukaryotes
Pairing-Dependent Intragenic Complementation
Summary
Meiotic Recombination: An Introduction To Meiosis
Crossingover And Chiasmata: Recombination Involves The Physical Interchange Of Genetic Material And Ensures Homolog Separation
The Classical Analysis Of Recombination
Measuring The Frequency Of Recombination
The Mechanism Of Recombination
Summary
Meiotic Chromosome Segregation: Types And Consequences Of Failed Segregation
The Origin Of Spontaneous Non-Disjunction
The Centromere
Segregational Mechanisms
Summary
Epilogue
References
Partial author index
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.