Clinical Chemistry : Concepts and Applications,9780071360470

Clinical Chemistry : Concepts and Applications

by ;
ISBN13: 9780071360470
ISBN10: 0071360476
Format: Hardcover
Pub. Date: 2002-12-02
Publisher(s): McGraw-Hill Medical
List Price: $82.95

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Summary

Offers students an expert treatment of the theory, concepts, correlations, and applications of clinical laboratory science. The book explains the principles of analytical techniques, and presents a wealth of pedagogical features, including chapter outlines, end-of-chapter reviews, and concept applications.

Author Biography

Shauna C. Anderson, PhD Professor, Department of Microbiology, Brigham Young University, Provo, Utah Susan Cockayne, PhD Associate Professor, Department of Microbiology, Brigham Young University, Provo, Utah

Table of Contents

Contributors xi
Foreword xiii
Preface xv
Acknowledgments xvii
Laboratory Resources
1(16)
Mary Coleman
Pipets
1(4)
Dispensers
5(1)
Glassware and Plasticware
6(1)
Cleaning Labware
7(1)
Chemical Reagents and Handling
8(1)
Reference Materials and Controls
9(1)
Water Purification
10(1)
Basic Chemistry Equipment
11(2)
Centrifuges
13(2)
Summary
15(2)
Laboratory Reagents and Calculations
17(10)
Susan Cockayne
Reagents
17(1)
Standards
17(1)
Laboratory Calculations
17(9)
Summary
26(1)
Laboratory Safety
27(14)
Jean D. Holter
Regulations
27(1)
Safety Practices
27(2)
Fire Safety
29(1)
Chemical Safety
30(5)
Compressed Gases
35(1)
Electrical Safety
35(1)
Biological Safety
36(1)
Radiation Safety
37(1)
Laboratory Safety Program
38(1)
Summary
38(1)
Resources for Safety Information
39(2)
Quality Assurance
41(24)
Mark D. Kellogg
The Quality Management Framework
41(1)
Quality Control Monitoring
42(20)
Summary
62(3)
Method Evaluation and Preanalytical Variables
65(16)
Mary Coleman
Method Evaluation
65(8)
Reference Intervals
73(1)
Preanalytical Variables
74(3)
Components of an Effective CQI/QA Program
77(1)
Summary
78(3)
Spectrophotometry
81(14)
Joan E. Aldrich
Spectrophotometric Principles
81(4)
Sepctrohotometric Instruments
85(8)
Summary
93(2)
Principles of Molecular and Immunoassays
95(36)
Audrey E. Hentzen
Introduction
95(3)
Specimen Collection and Handling
98(1)
Immunoassays
98(6)
Enzyme Labels
104(4)
Fluorescent Labels
108(2)
Molecular Assays
110(18)
Summary
128(3)
Laboratory Automation
131(10)
Jean D. Holter
Robotics
131(1)
Stages of Automated Analysis
132(4)
Examples of Specific Systems
136(2)
Instrument Selection
138(1)
Summary
138(3)
Computers in the Clinical Laboratory
141(12)
Mark D. Kellogg
Computer Hardware and Software
141(6)
Networking and Communication
147(4)
Laboratory Information Systems
151(1)
Medical Informatics
151(1)
Summary
152(1)
Carbohydrates
153(26)
Margot Hall
Definitions and Basic Principles
153(1)
Classification
153(3)
Metabolism
156(1)
Hormonal Regulation
157(2)
Clinical Applications
159(10)
Cerebrospinal Fluid Glucose
169(1)
Analytical Procedures
169(6)
Summary
175(4)
Lipids
179(24)
Richard C. Mroz, Jr.
Classification of Lipids
179(3)
Metabolism of Lipids
182(2)
Lipoproteins
184(4)
Analytical Procedures for Lipids
188(4)
Pathophysiology
192(6)
Summary
198(5)
Proteins
203(20)
Joan Radtke
Classification
203(3)
Metabolism: Synthesis and Degradation
206(1)
General Analytical Processes
206(5)
Clinical Applications
211(9)
Protein in Other Body Fluids
220(1)
Summary
221(2)
Inherited Metabolic Disorders
223(16)
Jane Adrian
Overview of Genetic Disorders
223(5)
Clinical Applications in Detecting Metabolic Related Disorders
228(8)
Analytical Procedures: Past, Present, and Anticipated
236(1)
Summary
237(2)
Immunologic Disorders
239(22)
Audrey E. Hentzen
Autoimmunity
239(5)
Clinical Applications
244(11)
Summary
255(6)
Clinical Enzymology
261(24)
Joan E. Aldrich
Measuring Enzymes
261(8)
Clinically Significant Enzymes
269(9)
Clinical Applications
278(5)
Summary
283(2)
Liver Function
285(38)
Lynn R. Ingram
Liver Anatomy
285(1)
Liver Function
286(4)
Analytical Procedures
290(7)
Clinical Applications
297(22)
Summary
319(4)
Tumor Markers
323(20)
Margot Hall
Characteristics of an Ideal Tumor Marker
324(1)
Uses of Tumor Markers
324(1)
Biologic Sources
324(1)
Classification
325(12)
Clinical Applications
337(2)
New Directions
339(1)
Summary
340(3)
Porphyrins
343(12)
Susan Cockayne
Biosynthesis of Porphyrins and Heme
345(1)
Clinical Applications
346(3)
Laboratory Diagnosis of Porphyrin Disorders
349(1)
Analytical Procedures
350(3)
Summary
353(2)
Renal Anatomy and Physiology
355(18)
Nancy A. Brunzel
Renal Anatomy
355(7)
Renal Physiology
362(9)
Summary
371(2)
Renal Function: Nonprotein Nitrogen Compounds, Function Tests, and Renal Disease
373(28)
Nancy A. Brunzel
Nonprotein Nitrogen Compounds
373(7)
Assessment of Renal Function
380(11)
Clinical Applications
391(6)
Summary
397(4)
Electrolytes
401(20)
Richard C. Mroz, Jr.
Total Body Water
401(1)
Osmolality
401(1)
Electrolytes
402(14)
Analytical Procedures
416(3)
Summary
419(2)
Acid-Base and Blood Gas Physiology
421(20)
Lisa J. Johnson
Clinical Important Gases
421(5)
Maintenance of Acid-Base Balance
426(5)
Disturbances of Acid-Base Balance
431(4)
Laboratory Evalaution
435(3)
The Extended Laboratory
438(3)
Therapeutic Drug Monitoring
441(14)
Susan Cockayne
Drug Action
441(1)
Drug Disposition
442(3)
Pharmacokinetics
445(2)
Variable Affecting Drug Disposition
447(1)
Sample Collection and Data Reporting
447(1)
Therapeutic Drug Monitoring
448(4)
Summary
452(3)
Toxicology
455(22)
Joan Radtke
Classes of Toxic Substances
455(11)
Drugs of Abuse and Overdose
466(5)
Analytical Procedures
471(3)
Summary
474(3)
Introduction to Hormones and Endocrinology
477(6)
Jocelyn J. Hulsebus
Classification of Hormones
477(3)
Regulation of Hormone Secretion
480(1)
Mechanisms of Action
480(1)
Disorders of the Endocrine System
481(1)
Summary
481(2)
Hypothalamus and Pituitary Endocrinology
483(8)
Jocelyn J. Hulsebus
Hypothalamus
483(1)
Pineal Gland
483(1)
Pituitary (Hypophysis) Gland
483(6)
Summary
489(2)
Thyroid Endocrinology
491(20)
Marcia H. Hicks
Thyroid Anatomy
491(1)
Thyroid Physiology
491(5)
Thyroid Function Testing
496(5)
Clinical Applications
501(7)
Summary
508(3)
The Parathyroid Glands and Calcium-Phosphate Metabolism
511(10)
Susan Cockayne
Shauna C. Anderson
Anatomy
511(1)
Parathyroid Hormone
511(1)
Regulation of Calcium and Phosphorus
511(2)
Specific Analytes
513(2)
Clinical Applications
515(4)
Summary
519(2)
Adrenocortical Endocrinology
521(10)
Jocelyn J. Hulsebus
Anatomy
521(1)
Adrenal Hormones
521(4)
Adrenal Function Tests
525(1)
Clinical Applications
526(2)
Summary
528(3)
Adrenal Medullary Endocrinology
531(6)
Jocelyn J. Hulsebus
Anatomy
531(1)
Adrenal Medullary Hormones
531(3)
Clinical Applications
534(1)
Summary
535(2)
Reproductive Endocrinology
537(20)
George B. Kudolo
Male Reproductive System
537(3)
Female Reproductive System
540(4)
Structure and Function of Gonadal Steroids
544(3)
Mechanism of Hormone Action
547(2)
Analytes
549(2)
Clinical Applications
551(2)
Defects of Androgen Metabolism
553(1)
Gonadal Function Tests
554(1)
Summary
554(3)
Gastrointestinal and Pancreatic Function
557(22)
Claudia E. Miller
Gastrointestinal Organs
557(3)
Accessory Organs
560(1)
Digestion
561(1)
Regulation of Digestion by Gastrointestinal Hormones
562(1)
Clinical Applications
563(7)
Laboratory Diagnosis of Dysfunction
570(7)
Summary
577(2)
Nutritional Status Assessment
579(34)
Sharon M. Miller
Elia Mears
Nutritional Status
579(1)
Proteins
580(6)
Vitamins and Mineral Status
586(14)
Trace and Ultratrace Elements
600(8)
Summary
608(5)
Point-of-Care Testing
613(6)
Jean D. Holter
The POCT Laboratory
613(1)
Evaluation
614(2)
POCT Testing and Instrumentation
616(1)
Biling
617(1)
Summary
617(2)
Laboratory Assessment of Psychiatric Disorders
619(6)
Jane Adrian
Supporting the Psychiatric Diagnosis and Plan of Treatment
619(1)
Medical Conditions Underlying Diagnosis and Treatment
620(1)
Screening for the Biochemical Basis of Psychiatric Disorders
621(1)
Monitoring Therapeutic Treatment
622(1)
Summary
623(2)
Biochemical Assessment During Pregnancy
625(12)
George B. Kudolo
Biochemical Changes
625(4)
Analytes
629(4)
Clinical Applications
633(2)
Summary
635(2)
Neonatal and Pediatric Laboratory Assessment
637(12)
Eileen Carreiro-Lawandowski
Developmental Differences
637(1)
Perintal Physiology
637(3)
Laboratory Assessment in the Pediatric Population
640(6)
Summary
646(3)
Geriatric Laboratory Assessment
649(38)
Sharon M. Miller
The ``New'' Elderly
649(2)
Theories of Aging
651(3)
Biochemical Changes
654(16)
Nutrition in Aging
670(1)
Vitamin Status
671(5)
Reference Ranges
676(1)
Clinical Applications
677(4)
Summary
681(6)
Index 687

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