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Summary

The "bible" on diabetes mellitus is now in its Fourteenth Edition--thoroughly revised and updated by more than 80 noted experts from the Joslin Diabetes Center and other leading institutions worldwide. This edition includes a new eleven-chapter section on hormone action and the regulation of metabolism. The section on definition and pathogenesis now includes chapters on genetics, diabetes in Asia and Africa, and diabetes in U.S. minority groups. Other new chapters cover retinopathy, cardiovascular disease, wound healing, and treatment of women with diabetes. All of the Fourteenth Edition's figures have been completely updated.

Table of Contents

Preface v
Contributors vii
The History of Diabetes
1(18)
Donald M. Barnett
Leo P. Krall
SECTION I: BASIC MECHANISMS OF ISLET DEVELOPMENT AND FUNCTION
19(106)
Development of the Endocrine Pancreas
21(20)
Ondine Cleaver
Douglas A. Melton
Islets of Langerhans: Morphology and Postnatal Growth
41(12)
Susan Bonner-Weir
Genetic Regulation of Islet Function
53(12)
Michael S. German
Insulin Biosynthesis, Processing, and Chemistry
65(18)
Christopher J. Rhodes
Steven E. Shoelson
Philippe A. Halban
Cell Biology of Insulin Secretion
83(26)
Jean-Claude Henquin
Insulin Secretion In Vivo
109(16)
Melissa K. Cavaghan
Kenneth S. Polonsky
SECTION II: HORMONE ACTION AND THE REGULATION OF METABOLISM
125(204)
Hormone--Fuel Interrelationships: Fed State, Starvation, and Diabetes Mellitus
127(18)
Neil B. Ruderman
Martin G. Myers, Jr.
Stuart R. Chipkin
Keith Tornheim
The Molecular Mechanism of Insulin Action and the Regulation of Glucose and Lipid Metabolism
145(24)
C. Ronald Kahn
Alan R. Saltiel
Insulin-like Growth Factors
169(10)
Karen C. McCowen
Robert J. Smith
Glucagon and Glucagon-like Peptides
179(16)
Joel F. Habener
Timothy J. Kieffer
Magnetic Resonance Spectroscopy Studies of Liver and Muscle Glycogen Metabolism in Humans
195(12)
Roy Taylor
Gerald I. Shulman
Biology of Adipose Tissue
207(20)
Sheila Collins
Rexford S. Ahima
Barbara B. Kahn
Biology of Skeletal Muscle
227(16)
Alison C. Jozsi
Laurie J. Goodyear
Regulation of Hepatic Glucose Metabolism
243(22)
Daryl K. Granner
Donald K. Scott
Fat Metabolism in Diabetes
265(10)
Ananda Basu
Michael D. Jensen
Alterations in Protein Metabolism in Diabetes Mellitus
275(16)
Craig S. Stump
K. Sreekumaran Nair
Rodent Models for the Study of Diabetes
291(38)
Clayton E. Mathews
Edward H. Leiter
SECTION III: DIABETES: DEFINITION, GENETICS, AND PATHOGENESIS
329(202)
Definition, Diagnosis, and Classification of Diabetes Mellitus and Glucose Homeostasis
331(10)
Peter H. Bennett
William C. Knowler
Epidemiology of Diabetes Mellitus
341(14)
James H. Warram
Andrzej S. Krolewski
Genetics of Type 1 Diabetes
355(16)
Helena Reijonen
Patrick Concannon
Genetics of Type 2 Diabetes
371(28)
Alessandro Doria
Type 1 Diabetes Mellitus
399(26)
George S. Eisenbarth
Insulin Resistance and Its Role in the Pathogenesis of Type 2 Diabetes
425(24)
Meredith Hawkins
Luciano Rossetti
β-Cell Dysfunction in Type 2 Diabetes Mellitus
449(14)
Jack L. Leahy
Maturity-Onset Diabetes of the Young
463(14)
Andrew T. Hattersley
Secondary Forms of Diabetes
477(16)
Om P. Ganda
Syndromes of Extreme Insulin Resistance
493(12)
Allison B. Goldfine
Alan C. Moses
Diabetes in Minorities in the United States
505(20)
A. Enrique Caballero
Diabetes---A Worldwide Problem
525(6)
Paul Zimmet
Jonathan Shaw
SECTION IV: OBESITY AND LIPOPROTEIN DISORDERS
531(54)
Obesity
533(14)
Eleftheria Maratos-Flier
Jeffrey S. Flier
Treatment of Obesity
547(16)
Xavier Pi-Sunyer
Pathophysiology and Treatment of Lipid Disorders in Diabetes
563(22)
Barbara V. Howard
Wm. James Howard
SECTION V: TREATMENT OF DIABETES MELLITUS
585(208)
General Approach to the Treatment of Diabetes Mellitus
587(10)
Ramachandiran Cooppan
Education in the Treatment of Diabetes
597(14)
Richard S. Beaser
Katie Weinger
Lisa M. Bolduc-Bissell
Medical Nutrition Therapy
611(22)
Karen Hanson Chalmers
Behavioral Research and Psychological Issues in Diabetes: Progress and Prospects
633(16)
Barbara J. Anderson
Ann E. Goebel-Fabbri
Alan M. Jacobson
Exercise in Patients with Diabetes Mellitus
649(10)
Jeanne H. Steppel
Edward S. Horton
Principles of Insulin Therapy
659(12)
Alice Y. Y. Cheng
Bernard Zinman
Iatrogenic Hypoglycemia
671(16)
Stephanie Anne Amiel
Management of Hyperglycemia with Oral Antihyperglycemic Agents in Type 2 Diabetes
687(24)
Harold E. Lebovitz
Treatment of the Child and Adolescent with Diabetes
711(26)
Lori Laffel
Cindy Pasquarello
Margaret Lawlor
Treatment of Older Adults with Diabetes
737(10)
Caroline S. Blaum
Jeffrey B. Halter
Women's Health Issues in Diabetes Mellitus
747(18)
Julie Lund Sharpless
Pancreas and Islet Transplantation
765(12)
Gordon C. Weir
Diabetes and the Healthcare System: Economic and Social Costs
777(16)
James L. Rosenzweig
SECTION VI: BIOLOGY OF THE COMPLICATIONS OF DIABETES
793(92)
Epidemiology of Late Complications of Diabetes: A Basis for the Development and Evaluation of Preventive Programs
795(14)
Andrzej S. Krolewski
James H. Warram
Relationship between Metabolic Control and Long-Term Complications of Diabetes
809(14)
David M. Nathan
Mechanisms of Diabetic Microvascular Complications
823(16)
Christian Rask-Madsen
Zhiheng He
George L. King
Pathogenesis of Diabetic Neuropathy
839(14)
Phillip A. Low
Pathogenesis of Diabetic Nephropathy
853(14)
Gabriella Gruden
GianCarlo Viberti
Pathogenesis of Cardiovascular Disease in Diabetes
867(18)
Edward P. Feener
Victor J. Dzau
SECTION VII: DIABETIC COMPLICATIONS: CLINICAL ASPECTS
885(260)
Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State
887(14)
Jennifer Wyckoff
Martin J. Abrahamson
Ocular Complications of Diabetes Mellitus
901(24)
Lloyd M. Aiello
Lloyd Paul Aiello
Jerry D. Cavallerano
Management of Diabetic Kidney Disease
925(26)
Mark E. Williams
Robert C. Stanton
The Nervous System and Diabetes
951(18)
Roy Freeman
Hypertension in Diabetes Mellitus
969(6)
Samy I. McFarlane
Jonathan Castro
Dmitri Kirpichnikov
James R. Sowers
Diabetes Mellitus and Heart Disease
975(24)
Michael T. Johnstone
Richard Nesto
Erectile Dsyfunction and Diabetes
999(18)
Ricardo Munarriz
Abdulmaged Traish
Irwin Goldstein
Infection and Diabetes
1017(18)
Deborah E. Sentochnik
George M. Eliopoulos
Diabetes and Pregnancy
1035(14)
Florence M. Brown
Allison B. Goldfine
Cutaneous Manifestations of Diabetes Mellitus
1049(12)
Mark H. Lowitt
Jeffrey S. Dover
Joint and Bone Manifestations of Diabetes Mellitus
1061(8)
M. Elaine Husni
Susan F. Kroop
Lee S. Simon
Effects of Diabetes Mellitus on the Digestive System
1069(34)
Hiroshi Mashimo
Roger J. May
Raj K. Goyal
Treatment of Diabetes in the Hospitalized Patient
1103(8)
Howard A. Wolpert
The Diabetic Foot: Strategies for Treatment and Prevention of Ulcerations
1111(12)
John M. Giurini
Vascular Disease of the Lower Extremities in Diabetes Mellitus: Etiology and Management
1123(10)
Cameron M. Akbari
Frank W. LoGerfo
Diabetes Mellitus and Wound Healing
1133(12)
Parham A. Ganchi
Elof Eriksson
SECTION VIII: HYPOGLYCEMIA AND ISLET CELL TUMORS
1145(44)
Hypoglycemia
1147(30)
Benjamin Glaser
Gil Leibowitz
Endocrine Tumors of the Pancreas
1177(12)
Maha T. Barakat
Houman Ashrafian
Stephen R. Bloom
Index 1189

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