Preface |
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v | |
Contributors |
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vii | |
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1 | (18) |
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SECTION I: BASIC MECHANISMS OF ISLET DEVELOPMENT AND FUNCTION |
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19 | (106) |
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Development of the Endocrine Pancreas |
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21 | (20) |
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Islets of Langerhans: Morphology and Postnatal Growth |
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41 | (12) |
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Genetic Regulation of Islet Function |
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53 | (12) |
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Insulin Biosynthesis, Processing, and Chemistry |
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65 | (18) |
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Cell Biology of Insulin Secretion |
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83 | (26) |
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Insulin Secretion In Vivo |
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109 | (16) |
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SECTION II: HORMONE ACTION AND THE REGULATION OF METABOLISM |
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125 | (204) |
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Hormone--Fuel Interrelationships: Fed State, Starvation, and Diabetes Mellitus |
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127 | (18) |
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The Molecular Mechanism of Insulin Action and the Regulation of Glucose and Lipid Metabolism |
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145 | (24) |
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Insulin-like Growth Factors |
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169 | (10) |
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Glucagon and Glucagon-like Peptides |
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179 | (16) |
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Magnetic Resonance Spectroscopy Studies of Liver and Muscle Glycogen Metabolism in Humans |
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195 | (12) |
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Biology of Adipose Tissue |
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207 | (20) |
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Biology of Skeletal Muscle |
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227 | (16) |
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Regulation of Hepatic Glucose Metabolism |
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243 | (22) |
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Fat Metabolism in Diabetes |
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265 | (10) |
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Alterations in Protein Metabolism in Diabetes Mellitus |
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275 | (16) |
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Rodent Models for the Study of Diabetes |
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291 | (38) |
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SECTION III: DIABETES: DEFINITION, GENETICS, AND PATHOGENESIS |
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329 | (202) |
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Definition, Diagnosis, and Classification of Diabetes Mellitus and Glucose Homeostasis |
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331 | (10) |
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Epidemiology of Diabetes Mellitus |
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341 | (14) |
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Genetics of Type 1 Diabetes |
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355 | (16) |
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Genetics of Type 2 Diabetes |
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371 | (28) |
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399 | (26) |
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Insulin Resistance and Its Role in the Pathogenesis of Type 2 Diabetes |
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425 | (24) |
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β-Cell Dysfunction in Type 2 Diabetes Mellitus |
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449 | (14) |
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Maturity-Onset Diabetes of the Young |
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463 | (14) |
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Secondary Forms of Diabetes |
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477 | (16) |
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Syndromes of Extreme Insulin Resistance |
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493 | (12) |
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Diabetes in Minorities in the United States |
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505 | (20) |
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Diabetes---A Worldwide Problem |
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525 | (6) |
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SECTION IV: OBESITY AND LIPOPROTEIN DISORDERS |
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531 | (54) |
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533 | (14) |
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547 | (16) |
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Pathophysiology and Treatment of Lipid Disorders in Diabetes |
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563 | (22) |
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SECTION V: TREATMENT OF DIABETES MELLITUS |
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585 | (208) |
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General Approach to the Treatment of Diabetes Mellitus |
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587 | (10) |
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Education in the Treatment of Diabetes |
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597 | (14) |
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Medical Nutrition Therapy |
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611 | (22) |
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Behavioral Research and Psychological Issues in Diabetes: Progress and Prospects |
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633 | (16) |
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Exercise in Patients with Diabetes Mellitus |
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649 | (10) |
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Principles of Insulin Therapy |
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659 | (12) |
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671 | (16) |
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Management of Hyperglycemia with Oral Antihyperglycemic Agents in Type 2 Diabetes |
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687 | (24) |
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Treatment of the Child and Adolescent with Diabetes |
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711 | (26) |
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Treatment of Older Adults with Diabetes |
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737 | (10) |
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Women's Health Issues in Diabetes Mellitus |
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747 | (18) |
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Pancreas and Islet Transplantation |
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765 | (12) |
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Diabetes and the Healthcare System: Economic and Social Costs |
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777 | (16) |
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SECTION VI: BIOLOGY OF THE COMPLICATIONS OF DIABETES |
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793 | (92) |
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Epidemiology of Late Complications of Diabetes: A Basis for the Development and Evaluation of Preventive Programs |
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795 | (14) |
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Relationship between Metabolic Control and Long-Term Complications of Diabetes |
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809 | (14) |
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Mechanisms of Diabetic Microvascular Complications |
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823 | (16) |
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Pathogenesis of Diabetic Neuropathy |
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839 | (14) |
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Pathogenesis of Diabetic Nephropathy |
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853 | (14) |
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Pathogenesis of Cardiovascular Disease in Diabetes |
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867 | (18) |
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SECTION VII: DIABETIC COMPLICATIONS: CLINICAL ASPECTS |
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885 | (260) |
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Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State |
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887 | (14) |
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Ocular Complications of Diabetes Mellitus |
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901 | (24) |
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Management of Diabetic Kidney Disease |
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925 | (26) |
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The Nervous System and Diabetes |
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951 | (18) |
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Hypertension in Diabetes Mellitus |
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969 | (6) |
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Diabetes Mellitus and Heart Disease |
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975 | (24) |
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Erectile Dsyfunction and Diabetes |
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999 | (18) |
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1017 | (18) |
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1035 | (14) |
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Cutaneous Manifestations of Diabetes Mellitus |
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1049 | (12) |
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Joint and Bone Manifestations of Diabetes Mellitus |
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1061 | (8) |
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Effects of Diabetes Mellitus on the Digestive System |
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1069 | (34) |
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Treatment of Diabetes in the Hospitalized Patient |
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1103 | (8) |
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The Diabetic Foot: Strategies for Treatment and Prevention of Ulcerations |
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1111 | (12) |
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Vascular Disease of the Lower Extremities in Diabetes Mellitus: Etiology and Management |
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1123 | (10) |
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Diabetes Mellitus and Wound Healing |
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1133 | (12) |
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SECTION VIII: HYPOGLYCEMIA AND ISLET CELL TUMORS |
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1145 | (44) |
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1147 | (30) |
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Endocrine Tumors of the Pancreas |
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1177 | (12) |
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Index |
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1189 | |