Roitt's Essential Immunology - the textbook of choice for students and instructors of immunology worldwide 

Roitt’s Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications.  A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole.  Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer, immunodeficiency, allergies and transplantation and the beneficial effects of vaccines.

The 13^th edition continues to be a user-friendly and engaging introduction to the workings of the immune system, whilst supporting those who require a slightly more detailed understanding of the key developments in immunology.  The content has been fully updated throughout and includes:

• An expansion on key clinical topics, including: innate immunity, autoimmune conditions, asthma, primary immunodeficiency, and HIV/AIDS
• Beautifully presented with improved artwork and new illustrations
• A range of learning features, including introduction re-cap boxes, end of chapter and section summaries to aid revision, as well as further reading suggestions, and a glossary to explain the most important immunology terms.

Roitt's Essential Immunology is also supported by a companion website at www.roitt.com including:

• An additional online only chapter on immunological methods and applications 
• Further interactive multiple choice and single best answer questions for each chapter
• Animations and videos showing key concepts
• Fully downloadable figures and illustrations, further reading and useful links
• Updated extracts from the Encyclopaedia of Life Sciences
• Podcasts to reinforce the key principles explained in the text

Peter J. Delves PhD
Division of Infection and Immunity
UCL, London, UK

Seamus J. Martin PhD, FTCD, MRIA
The Smurfit Institute of Genetics
Trinity College, Dublin, Ireland

Dennis R. Burton PhD
Department of Immunology and Microbial Science
The Scripps Research Institute
La Jolla, California, USA

Ivan M. Roitt MA, DSc(Oxon), FRCPath, Hon FRCP (Lond), FRS
Centre for Investigative and Diagnostic Oncology
Middlesex University, London, UK

About the authors vi

Acknowledgments viii

Preface ix

Abbreviations x

How to use your textbook xvi

About the companion website xvii

Part 1: Fundamentals of immunology 1

1 Innate immunity 3

2 Specific acquired immunity 52

3 Antibodies 69

4 Membrane receptors for antigen 97

5 Antigen‐specific recognition 139

6 The anatomy of the immune response 167

7 Lymphocyte activation 187

8 The production of effectors 218

9 The regulation of the immune response 272

10 Development and evolution of the immune response 291

Part 2: Applied immunology 319

11 Adversarial strategies during infection 321

12 Vaccines 353

13 Immunodeficiency 378

14 Allergy and other hypersensitivities 405

15 Transplantation 435

16 Tumor immunology 458

17 Autoimmune diseases 499

Glossary 529

Index 541