| Preface |
|
vii | (2) |
| Contributors |
|
ix | |
| PART I. INTRODUCTION |
|
3 | (6) |
|
1. The Diagnostic and Therapeutic Approach to Hematologic Problems |
|
|
|
|
|
|
|
| PART II. LABORATORY HEMATOLOGY |
|
9 | (136) |
|
2. Examination of the Blood and Bone Marrow |
|
|
9 | (27) |
|
|
|
|
|
|
|
|
36 | (20) |
|
|
|
|
|
|
|
|
|
|
|
4. Clinical Flow Cytometry |
|
|
56 | (16) |
|
|
|
|
|
|
5. Clusters of Differentiation |
|
|
72 | (26) |
|
|
|
|
|
|
|
|
98 | (26) |
|
|
|
|
|
|
7. Molecular Genetics and Hematology |
|
|
124 | (21) |
|
Rebecca L.Shattuck-Brandt |
|
|
|
|
|
|
|
|
|
| PART III. THE NORMAL HEMATOLOGIC SYSTEM |
|
145 | (752) |
| Section 1. Hematopoiesis |
|
|
8. Origin and Development of Blood Cells |
|
|
145 | (24) |
|
|
|
|
|
|
|
|
|
|
| Section 2. The Erythrocyte |
|
|
|
|
169 | (24) |
|
|
|
|
|
|
10. The Mature Erythrocyte |
|
|
193 | (35) |
|
|
|
|
|
|
|
|
|
|
|
11. Nutritional Factors in the Production and Function of Erythrocytes |
|
|
228 | (39) |
|
|
|
|
|
|
|
|
|
|
|
12. Destruction of Erythrocytes |
|
|
267 | (33) |
|
|
|
|
|
| Section 3. Granulocytes and Monocytes |
|
|
13. Neutrophilic Leukocytes |
|
|
300 | (51) |
|
|
|
|
|
|
|
|
351 | (11) |
|
|
|
|
|
|
|
|
|
|
|
15. Basophilic Leukocytes: Mast Cells and Basophils |
|
|
362 | (15) |
|
|
|
|
|
|
|
|
|
|
|
16. Mononuclear Phagocytes |
|
|
377 | (38) |
|
|
|
|
|
|
|
|
415 | (15) |
|
|
|
|
|
| Section 4. The Lymphocytes |
|
|
|
|
430 | (34) |
|
|
|
|
|
|
|
|
|
|
|
|
|
464 | (33) |
|
|
|
|
|
|
20. T Lymphocytes and NK Cells |
|
|
497 | (47) |
|
|
|
|
|
|
21. Cell Interactions in the Immune Response |
|
|
544 | (71) |
|
|
|
|
|
| Section 5. Hemostasis |
|
|
22. Platelets and Megakaryocytes |
|
|
615 | (46) |
|
|
|
|
|
|
|
|
|
|
|
23. Platelets in Hemostasis and Thrombosis |
|
|
661 | (23) |
|
|
|
|
|
|
Christel Boudignon-Proudhon |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
24. Blood Coagulation and Fibrinolysis |
|
|
684 | (81) |
|
|
|
|
|
|
|
|
|
|
|
25. Endothelium and the Regulation of Hemostasis |
|
|
765 | (9) |
|
|
|
|
|
| Section 6. Transfusion and Transplantation |
|
|
26. Red Cell, Platelet, and White Cell Antigens |
|
|
774 | (43) |
|
|
|
|
|
|
27. Principles and Practice of Transfusion Medicine |
|
|
817 | (58) |
|
|
|
|
|
|
28. Hematopoietic Stem Cell Transplantation |
|
|
875 | (22) |
|
|
|
|
|
| PART IV. DISORDERS OF RED CELLS |
|
897 | (660) |
| Section 1. Anemia: General Considerations |
|
|
29. Anemia: General Aspects |
|
|
897 | (11) |
|
|
|
|
|
|
30. Anemia: a Diagnostic Strategy |
|
|
908 | (33) |
|
|
|
|
|
| Section 2. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis |
|
|
31. Pernicious Anemia and Other Causes of Vitamin B12 (Cobalamin) Deficiency |
|
|
941 | (24) |
|
|
|
|
|
|
32. Folate Deficiency: Causes and Management |
|
|
965 | (8) |
|
|
|
|
|
|
33. Inherited and Drug-Induced Megaloblastic Anemia |
|
|
973 | (6) |
|
|
|
|
|
| Section 3. Disorders of Iron Metabolism and Heme Synthesis |
|
|
34. Iron Deficiency and Iron-Deficiency Anemia |
|
|
979 | (32) |
|
|
|
|
|
|
35. The Anemia of Chronic Disorders |
|
|
1011 | (11) |
|
|
|
|
|
|
36. Sideroblastic Anemias |
|
|
1022 | (24) |
|
|
|
|
|
|
37. Methemoglobinemia and Other Disorders Accompanied by Cyanosis |
|
|
1046 | (10) |
|
|
|
|
|
|
|
|
1056 | (15) |
|
|
|
|
|
|
|
|
1071 | (38) |
|
|
|
|
|
|
|
|
|
|
| Section 4. Hemolytic Anemia |
|
|
40. Hemolytic Disorders: General Considerations |
|
|
1109 | (23) |
|
|
|
|
|
|
41. Hereditary Spherocytosis and Other Anemias Due to Abnormalities of the Red Cell Membrane |
|
|
1132 | (28) |
|
|
|
|
|
|
|
|
|
|
|
42. Hereditary Hemolytic Anemias Associated with Abnormalities of Erythrocyte Glycolysis and Nucleotide Metabolism |
|
|
1160 | (16) |
|
|
|
|
|
|
|
|
|
|
|
43. Glucose-6-Phosphate Dehydrogenase Deficiency and Related Disorders of Hexose Monophosphate Shunt and Glutathione Metabolism |
|
|
1176 | (15) |
|
|
|
|
|
|
|
|
|
|
|
44. Mechanisms of Immune Destruction of Erythrocytes |
|
|
1191 | (19) |
|
|
|
|
|
|
|
|
|
|
|
45. Alloimmune Hemolytic Disease of the Fetus and Newborn |
|
|
1210 | (23) |
|
|
|
|
|
|
46. Autoimmune Hemolytic Anemias |
|
|
1233 | (31) |
|
|
|
|
|
|
47. Paroxysmal Nocturnal Hemoglobinuria |
|
|
1264 | (25) |
|
|
|
|
|
|
|
|
|
|
|
48. Acquired Hemolytic Anemias Resulting from Direct Effects of Infectious, Chemical, or Physical Agents |
|
|
1289 | (16) |
|
|
|
|
|
|
49. Red Cell Fragmentation Syndromes |
|
|
1305 | (24) |
|
|
|
|
|
| Section 5. Hereditary Disorders of Hemoglobin Structure and Synthesis |
|
|
50. The Abnormal Hemoglobins: General Principles |
|
|
1329 | (17) |
|
|
|
|
|
|
51. Sickle Cell Anemia and Other Sickling Syndromes |
|
|
1346 | (52) |
|
|
|
|
|
|
|
|
|
|
|
52. Unstable Hemoglobin Disease |
|
|
1398 | (7) |
|
|
|
|
|
|
|
|
|
|
|
53. The Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis |
|
|
1405 | (44) |
|
|
|
|
|
| Section 6. Other Disorders Associated with Anemia |
|
|
54. Pancytopenia, Aplastic Anemia, and Pure Red Cell Aplasia |
|
|
1449 | (36) |
|
|
|
|
|
|
55. Acute Post-Hemorrhagic Anemia |
|
|
1485 | (4) |
|
|
|
|
|
|
56. Congenital Dyserythropoietic Anemias |
|
|
1489 | (8) |
|
|
|
|
|
|
57. The Anemias Associated with Renal Disease, Liver Disease, Endocrine Disease, and Pregnancy |
|
|
1497 | (21) |
|
|
|
|
|
|
58. Anemias Unique to Infants and Young Children |
|
|
1518 | (20) |
|
|
|
|
|
|
|
|
|
|
| Section 7. Erythrocytosis |
|
|
59. Polycythemia: Erythrocytosis |
|
|
1538 | (19) |
|
|
|
|
|
| PART V. DISORDERS OF HEMOSTASIS AND COAGULATION |
|
1557 | (264) |
| Section 1. Introduction |
|
|
60. The Diagnostic Approach to the Bleeding Disorders |
|
|
1557 | (22) |
|
|
|
|
|
|
|
|
|
|
| Section 2. Thrombocytopenia |
|
|
61. Thrombocytopenia: Pathophysiology and Classification |
|
|
1579 | (4) |
|
|
|
|
|
|
62. Thrombocytopenia Caused by Immunologic Platelet Destruction |
|
|
1583 | (29) |
|
|
|
|
|
|
63. Thrombotic Thrombocytopenic Purpura and Other Forms of Nonimmunologic Platelet Destruction |
|
|
1612 | (11) |
|
|
|
|
|
|
64. Miscellaneous Causes of Thrombocytopenia |
|
|
1623 | (10) |
|
|
|
|
|
| Section 3. Other Disorders of Primary Hemostasis |
|
|
65. Bleeding Disorders Caused by Vascular Abnormalities |
|
|
1633 | (15) |
|
|
|
|
|
|
|
|
|
|
|
|
|
1648 | (13) |
|
|
|
|
|
|
67. Qualitative Disorders of Platelet Function |
|
|
1661 | (21) |
|
|
|
|
|
| Section 4. Coagulation Disorders |
|
|
68. Inherited Coagulation Disorders |
|
|
1682 | (51) |
|
|
|
|
|
|
|
|
|
|
|
69. Acquired Coagulation Disorders |
|
|
1733 | (48) |
|
|
|
|
|
|
|
|
|
|
| Section 5. Thrombosis |
|
|
70. Thrombosis and Antithrombotic Therapy |
|
|
1781 | (40) |
|
|
|
|
|
| PART VI. NONMALIGNANT DISORDERS OF LEUKOCYTES, THE SPLEEN, AND/OR IMMUNOGLOBINS |
|
1821 | (172) |
|
71. Diagnostic Approach to Malignant and Nonmalignant Disorders of the Hematopoietic-Lymphoid System |
|
|
1821 | (15) |
|
|
|
|
|
|
|
|
|
|
|
72. Variations of Leukocytes in Disease |
|
|
1836 | (26) |
|
|
|
|
|
|
|
|
|
|
|
|
|
1862 | (27) |
|
|
|
|
|
|
74. Qualitative Disorders of Leukocytes |
|
|
1889 | (19) |
|
|
|
|
|
|
75. Abnormalities of the Monocyte-Macrophage System--The Lysosomal Storage Diseases |
|
|
1908 | (8) |
|
|
|
|
|
|
|
|
|
|
|
76. Langerhans Cell Histiocytosis |
|
|
1916 | (10) |
|
|
|
|
|
|
|
|
|
|
|
77. Infectious Mononucleosis |
|
|
1926 | (30) |
|
|
|
|
|
|
78. Hematologic Aspects of Acquired Immunodeficiency Disease |
|
|
1956 | (13) |
|
|
|
|
|
|
79. Disorders of the Spleen |
|
|
1969 | (24) |
|
|
|
|
|
|
|
|
|
|
| PART VII. HEMATOLOGIC MALIGNANCIES |
|
1993 | (745) |
| Section 1. General Aspects |
|
|
80. The Hematopoietic-Lymphoid Neoplasms |
|
|
1993 | (40) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
81. Complications of Hematopoietic Neoplasms |
|
|
2033 | (43) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
82. Principles and Pharmacology of Chemotherapy |
|
|
2076 | (26) |
|
|
|
|
|
|
83. Supportive Care in Hematologic Malignancies |
|
|
2102 | (55) |
|
|
|
|
|
|
|
|
2157 | (21) |
|
|
|
|
|
|
85. Gene Therapy for Hematologic Disorders, HIV Infection, and Cancer |
|
|
2178 | (31) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Section 2. The Acute Leukemias |
|
|
86. Classification and Differentiation of the Acute Leukemias |
|
|
2209 | (32) |
|
|
|
|
|
|
|
|
|
|
|
87. Acute Lymphocytic Leukemia |
|
|
2241 | (31) |
|
|
|
|
|
|
|
|
|
|
|
88. Acute Myelogenous Leukemia |
|
|
2272 | (48) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
89. The Myelodysplastic Syndromes |
|
|
2320 | (22) |
|
|
|
|
|
|
|
|
|
|
| Section 3. Myeloproliferative Disorders |
|
|
90. Chronic Myeloid Leukemia |
|
|
2342 | (32) |
|
|
|
|
|
|
|
|
|
|
|
|
|
2374 | (16) |
|
|
|
|
|
|
|
|
2390 | (15) |
|
|
|
|
|
|
|
|
|
|
| Section 4. Lymphoproliferative Disorders |
|
|
93. Chronic Lymphocytic Leukemia |
|
|
2405 | (23) |
|
|
|
|
|
|
|
|
2428 | (19) |
|
|
|
|
|
|
95. Non-Hodgkin Lymphomas |
|
|
2447 | (91) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2538 | (34) |
|
|
|
|
|
|
97. Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome |
|
|
2572 | (40) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Section 5. Plasma Cell Dyscrasias |
|
|
98. Plasma Cell Dyscrasias: General Considerations |
|
|
2612 | (19) |
|
|
|
|
|
|
|
|
2631 | (50) |
|
|
|
|
|
|
|
|
|
|
|
Waldenstrom Macroglobulinemia |
|
|
2681 | (12) |
|
|
|
|
|
|
101. Heavy Chain Diseases |
|
|
2681 | (12) |
|
|
|
|
|
|
|
|
2705 | (20) |
|
|
|
|
|
|
103. Cryoglobulins and Cryoglobulinemia |
|
|
2725 | (13) |
|
|
|
|
|
| APPENDICES |
|
2738 | |
| Appendix A. Normal Blood and Bone Marrow Values in Humans |
|
2738 | (11) |
|
|
|
|
|
| Appendix B. Comparative Hematology |
|
2749 | |
|
|
|
|
|
| INDEX |
|
i | |
Other versions by this Author